Fig 1: Immunohistochemical analysis of inflammatory infiltrates in AAA and healthy controls. (A-E) Grade 1, (F-J) grade 2 and (K-O) grade 3 lesions were stained with anti-NLRP3, anti-AIM2, anti-ASC, anti-Caspase-1 or anti-Caspase-5, as indicated. Scale bar, 100 µm. (P) Distribution of NLRP3+ cells, (Q) AIM2+ cells, (R) ASC+ cells, (S) Caspase-1+ cells, and (T) Caspase-5+ cells in grade 1, 2 and 3 lesions of AAA and control samples. **P<0.01 and ***P<0.001, comparisons are indicated by lines (Barnard's test). AAA, abdominal aortic aneurysm; NLRP3, NLR family pyrin domain containing 3; AIM2, absent in melanoma 2; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; ns, not significant.
Fig 2: Inflammasome-related protein expression frequencies decrease with AAA progression. Distribution of NLRP3, AIM2, ASC, Caspase-1 and Caspase-5 expression frequencies were determined by immunohistochem-istry as described in Fig. 3. For statistical analysis, the Fisher exact test (2×3 table) was used to detect heterogeneity across groups. For statistical calculations, the numbers listed in Table IV were used. Significant P-values indicate heterogeneity across the three groups (null hypothesis states that all groups are equal). AAA, abdominal aortic aneurysm; NLRP3, NLR family pyrin domain containing 3; AIM2, absent in melanoma 2; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain.
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