Anti-ZAP70 antibodies are used in the immunodetection of the protein zeta chain of T cell receptor associated protein kinase 70. In humans, the canonical protein has a reported length of 619 amino acid residues and a mass of 69.9 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in T- and natural killer cells. A member of the Tyr protein kinase protein family, ZAP70 is reported to be a tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Synonyms for this target antigen include IMD48, SRK, STCD, STD, TZK, tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, and ADMIO2. ZAP70 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 840 citations in the literature describe the use of ZAP70 antibodies in research. Flow Cytometry, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.