Anti-SORL1 antibodies are used in the immunodetection of the protein sortilin related receptor 1. In humans, the canonical protein has a reported length of 2214 amino acid residues and a mass of 248.4 kDa. It is reported to be highly expressed in the brain. A member of the VPS10-related sortilin protein family, SORL1 is reported to be a sorting receptor that directs several proteins to their correct location within the cell (Probable). Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation.
The SORL1 marker can be used to identify T Helper 17 Cells.* Synonyms for this target antigen include LR11, LRP9, SORLA, SorLA-1, gp250, and C11orf32. SORL1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SORL1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4