Anti-MYOG antibodies are used in the immunodetection of the protein myogenin. In humans, the canonical protein has a reported length of 224 amino acid residues and a mass of 25 kDa. Its subcellular localization is in the nucleus. MYOG is known to act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Post-translational modifications have been described, including phosphorylation.
The MYOG marker can be used to identify Myo-Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include bHLHc3, myf-4, class C basic helix-loop-helix protein 3, myogenic factor 4, and MYF4. MYOG gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 280 citations in the literature describe the use of Myog antibodies in research. Immunohistochemistry is a widely used application for these antibodies. In addition, Western Blot is also a common application.
*HuBMAP Human Reference Atlas v1.4