Anti-CASP6 antibodies are used in the immunodetection of the protein caspase 6. In humans, the canonical protein has a reported length of 293 amino acid residues and a mass of 33.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the appendix and colon. A member of the Peptidase C14A protein family, CASP6 is reported to be a cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity. Synonyms for this target antigen include MCH2, apoptotic protease MCH-2, caspase 6, apoptosis-related cysteine peptidase, caspase 6, apoptosis-related cysteine protease, mammalian Ced-3 homologue 2, and CSP-6. CASP6 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 260 citations in the literature describe the use of CASP6 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.