Anti-MEPE antibodies are used in the immunodetection of the protein matrix extracellular phosphoglycoprotein. In humans, the canonical protein has a reported length of 525 amino acid residues and a mass of 58.4 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 3 different isoforms have been reported for this protein. It is noted to be expressed by osteoblasts. A member of the PF07175/osteoregulin protein family, MEPE is reported to promote renal phosphate excretion and inhibits intestinal phosphate absorption. Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation.
The MEPE marker can be used to identify Amygdala Excitatory Neurons and Cerebral Cortex MGE Interneurons.* Synonyms for this target antigen include osteoblast/osteocyte factor 45, osteoregulin, and matrix, extracellular phosphoglycoprotein with ASARM motif (bone). MEPE gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4