Anti-HPA antibodies are used in antigen-specific immunodetection in biological samples. The target HPA is a known alias name of the protein heparanase, encoded by the HPSE gene in humans. This 543-amino acid residue protein is a reported endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. It is localized to the nucleus, lysosomes, membrane, and is secreted of the cell and features N-glycosylated and cleaved post-translational modifications. In terms of tissue expression, it is reported to be highly expressed in the placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. The term HPA1 is another synonym for HPA. Some HPA antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, and Immunohistochemistry are also common applications.