Anti-POMC antibodies are used in the immunodetection of the protein proopiomelanocortin. In humans, the canonical protein has a reported length of 267 amino acid residues and a mass of 29.4 kDa. It has been described to be a secreted protein. It is notably expressed in the pituitary gland. A member of the POMC protein family, POMC is known to be involved with cell to cell signaling and carbohydrate metabolism and homeostasis. Post-translational modifications have been described, including O-glycosylation and protein cleavage. The POMC gene has been associated with the disease, Obesity. Synonyms for this target antigen include ACTH and CLIP. POMC gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 120 citations in the literature describe the use of POMC antibodies in research. Immunohistochemistry is a widely used application for these antibodies. ELISA and Immunofluorescence are also common applications.