Anti-EZHIP antibodies are used in the immunodetection of the protein EZH inhibitory protein. In humans, the canonical protein has a reported length of 503 amino acid residues and a mass of 51.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is notably expressed in the testis, placenta, and ovary. EZHIP is reported to inhibit PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3). Synonyms for this target antigen include catalytic antagonist of Polycomb, uncharacterized protein CXorf67, and K27M-like inhibitor of PRC2. EZHIP gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.