Anti-COA8 antibodies are used in the immunodetection of the protein cytochrome c oxidase assembly factor 8. In humans, the canonical protein has a reported length of 206 amino acid residues and a mass of 24.2 kDa. Its subcellular localization is in the mitochondria. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in fibroblasts. A member of the COA8 protein family, Coa8 is known to be required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. Post-translational modifications have been described, including ubiquitination and protein cleavage. The COA8 gene has been associated with the disease, Mitochondrial complex IV deficiency. Synonyms for this target antigen include UPF0671 protein C14orf153 and apoptogenic 1, mitochondrial. COA8 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.