Anti-HROB antibodies are used in the immunodetection of the protein homologous recombination factor with OB-fold. In humans, the canonical protein has a reported length of 647 amino acid residues and a mass of 69.8 kDa. Its subcellular localization is in the nucleus and chromosomes. Up to 4 different isoforms have been reported for this protein. HROB is known to be a DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis. Synonyms for this target antigen include MCM8-9-Interacting Protein), homologous recombincation factor with OB-fold, uncharacterized protein C17orf53, and homologous recombination OB-fold protein. HROB gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.