Anti-VRK serine/threonine kinase 3 antibodies are used for the immunodetection of the protein encoded by the VRK3 gene. In humans, the canonical protein has a reported length of 474 amino acid residues and a mass of 52.9 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the CK1 Ser/Thr protein kinase protein family, it is reported to be an inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Other names for this target antigen include serine/threonine-protein kinase VRK3, serine/threonine-protein pseudokinase VRK3, vaccinia related kinase 3, and inactive serine/threonine-protein kinase VRK3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.