Anti-ADPRS antibodies are used in the immunodetection of the protein ADP-ribosylserine hydrolase. In humans, the canonical protein has a reported length of 363 amino acid residues and a mass of 38.9 kDa. Its subcellular localization is in the nucleus, mitochondria, and cytoplasm. It is ubiquitously expressed across many tissue types. A member of the ADP-ribosylglycohydrolase protein family, ADPRS is a reported ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. The ADPRS gene has been associated with the disease, Neurodegeneration. Synonyms for this target antigen include ARH3, CONDSIAS, ADP-ribosylhydrolase ARH3, ADP-ribose glycohydrolase ARH3, ADP-ribosylarginine hydrolase like 2, and ADPRHL2. ADPRS gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.