Anti-SRY-box transcription factor 5 antibodies are used for the immunodetection of the protein encoded by the SOX5 gene. In humans, the canonical protein has a reported length of 763 amino acid residues and a mass of 84 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 5 different isoforms for this protein. It is a reported transcription factor involved in chondrocytes differentiation and cartilage formation. The gene encoding this protein is implicated in Lamb-Shaffer syndrome. Other names for this target antigen include L-SOX5B, L-SOX5F, LAMSHF, transcription factor SOX-5, SRY (sex determining region Y)-box 5, SRY-box 5, and L-SOX5. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.