Anti-crumbs cell polarity complex component 2 antibodies are used for the immunodetection of the protein encoded by the CRB2 gene. In humans, the canonical protein has a reported length of 1285 amino acid residues and a mass of 134.3 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed in glomeruli, podocytes of the glomerular capillary loops, and parietal glomerular epithelial cells in the kidney. It is a member of the Crumbs protein family. Post-translational modifications have been described, including N-glycosylation. The gene encoding this protein is implicated in Focal segmental glomerulosclerosis. Other names for this target antigen include crumbs 2, cell polarity complex component, crumbs family member 2, crumbs-like protein 2, and protein crumbs homolog 2. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.