Anti-YARS1 antibodies are used in the immunodetection of the protein tyrosyl-tRNA synthetase 1. In humans, the canonical protein has a reported length of 528 amino acid residues and a mass of 59.1 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is notably widely expressed in many tissue types. A member of the Class-I aminoacyl-tRNA synthetase protein family, YARS1 is reported to be a Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). The YARS1 gene has been associated with the disease, Charcot-Marie-Tooth disease. Synonyms for this target antigen include IMNEPD2, TYRRS, YARS, YRS, YTS, tyrosine--tRNA ligase, cytoplasmic, tyrosine tRNA ligase 1, cytoplasmic, and CMTDIC. YARS1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.