Anti-macroH2A.1 histone antibodies are used for the immunodetection of the protein encoded by the MACROH2A1 gene. In humans, the canonical protein has a reported length of 369 amino acid residues and a mass of 39.2 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 3 different isoforms for this protein. It is widely expressed across many tissue types. A member of the Histone H2A protein family, it is known to be involved with DNA repair and the response to oxidative stress. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include H2A/y, H2AF12M, H2AFY, MACROH2A1.1, mH2A1, macroH2A1.2, core histone macro-H2A.1, and H2A.y. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.