Anti-MKS transition zone complex subunit 1 antibodies are used for the immunodetection of the protein encoded by the MKS1 gene. In humans, the canonical protein has a reported length of 559 amino acid residues and a mass of 64.5 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is a known component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. The gene encoding this protein is implicated in Meckel syndrome. Other names for this target antigen include JBTS28, MES, MKS, POC12, tectonic-like complex member MKS1, and BBS13. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.