Anti-methyltransferase 5, N6-adenosine antibodies are used for the immunodetection of the protein encoded by the METTL5 gene. In humans, the canonical protein has a reported length of 209 amino acid residues and a mass of 23.7 kDa. Its subcellular localization is in the nucleus. A member of the PrmA protein family, it is a known catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. The gene encoding this protein is implicated in Intellectual developmental disorder. Other names for this target antigen include MRT72, rRNA N6-adenosine-methyltransferase METTL5, methyltransferase like 5, methyltransferase-like protein 5, and HSPC133. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.