Anti-cellular communication network factor 6 antibodies are used for the immunodetection of the protein encoded by the CCN6 gene. In humans, the canonical protein has a reported length of 354 amino acid residues and a mass of 39.3 kDa. Its subcellular localization is in the mitochondria and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in adult kidney and testis and fetal kidney. A member of the CCN protein family, it is reported to play a role in mitochondrial electron transport and mitochondrial respiration. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Progressive pseudorheumatoid dysplasia. Other names for this target antigen include PPAC, PPD, PPRD, WISP-3, WISP3, CCN family member 6, WNT1 inducible signaling pathway protein 3, and LIBC. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.