Anti-PRAME nuclear receptor transcriptional regulator antibodies are used for the immunodetection of the protein encoded by the PRAME gene. In humans, the canonical protein has a reported length of 509 amino acid residues and a mass of 57.9 kDa. Its subcellular localization is in the cell membrane, nucleus, Golgi, and cytoplasm. It is notably expressed in the testis. A member of the PRAME protein family, it is known to be involved with the apoptotic pathway and cell differentiation. Other names for this target antigen include MAPE, OIP-4, OIP4, melanoma antigen preferentially expressed in tumors, Opa-interacting protein OIP4, and CT130.