Anti-modulator of VRAC current 1 antibodies are used for the immunodetection of the protein encoded by the MLC1 gene. In humans, the canonical protein has a reported length of 377 amino acid residues and a mass of 41.1 kDa. Its subcellular localization is in the cell membrane, ER, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus. It is reported to regulate the response of astrocytes to hypo-osmosis by promoting calcium influx. The gene encoding this protein is implicated in Leukoencephalopathy. Other names for this target antigen include MLC, VL, membrane protein MLC1, megalencephalic leukoencephalopathy with subcortical cysts 1, and LVM. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.