Anti-colony stimulating factor 2 receptor subunit beta antibodies are used for the immunodetection of the protein encoded by the CSF2RB gene. In humans, the canonical protein has a reported length of 897 amino acid residues and a mass of 97.3 kDa. Its subcellular localization is in the membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Type I cytokine receptor protein family, it is a reported cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Post-translational modifications have been described, including phosphorylation and glycosylation. The gene encoding this protein is implicated in Pulmonary surfactant metabolism dysfunction. Other names for this target antigen include CDw131, IL3RB, IL5RB, SMDP5, betaGMR, and CD131. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species.