Anti-RNF8 antibodies are used in the immunodetection of the protein ring finger protein 8. In humans, the canonical protein has a reported length of 485 amino acid residues and a mass of 55.5 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the RNF8 protein family, it is known to be involved with the cell cycle. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include E3 ubiquitin-protein ligase RNF8, C3HC4-type zinc finger protein, RING-type E3 ubiquitin transferase RNF8, UBC13/UEV-interacting ring finger protein, and hRNF8.