Anti-H1-5 antibodies are used in the immunodetection of the protein H1.5 linker histone, cluster member. In humans, the canonical protein has a reported length of 226 amino acid residues and a mass of 22.6 kDa. Its subcellular localization is in the nucleus and chromosomes. It is ubiquitously expressed across many tissue types. A member of the Histone H1/H5 protein family, H1-5 is known to be involved with chromatin organization and muscle organ development. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include H1.5, H1B, H1F5, H1s-3, HIST1H1B, histone H1.5, H1 histone family, member 5, and H1. H1-5 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.