Anti-Beta-Secretase 1 antibodies are used for the immunodetection of the protein encoded by the BACE1 gene. In humans, the canonical protein has a reported length of 501 amino acid residues and a mass of 55.8 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 6 different isoforms for this protein. It is notably expressed at high levels in the brain and pancreas. A member of the Peptidase A1 protein family, it is known to be important for the proteolytic processing of the amyloid precursor protein (APP). Post-translational modifications have been described, including N-glycosylation, ubiquitination, palmitoylation, acetylation and phosphorylation. Other names for this target antigen include BACE, HSPC104, APP beta-secretase, asp 2, aspartyl protease 2, and ASP2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 430 citations in the literature describe the use of Beta-Secretase 1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.