Anti-CALR antibodies are used in the immunodetection of the protein calreticulin. In humans, the canonical protein has a reported length of 417 amino acid residues and a mass of 48.1 kDa. Its subcellular localization is in the ER, cytoplasm, and is secreted. It is notably widely expressed in many tissue types. A member of the Calreticulin protein family, CALR is reported to be a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Post-translational modifications have been described, including glycosylation. The CALR marker can be used to identify Granulocyte-Macrophages Progenitor Cells (GMP) and Mesothelial Cells.* Synonyms for this target antigen include HEL-S-99n, RO, SSA, cC1qR, CRP55, ERp60, HACBP, and CRT. CALR gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4