Anti-SETDB2 antibodies are used in the immunodetection of the protein SET domain bifurcated histone lysine methyltransferase 2. In humans, the canonical protein has a reported length of 719 amino acid residues and a mass of 81.9 kDa. Its subcellular localization is in the nucleus and chromosomes. Up to 3 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the Class V-like SAM-binding methyltransferase protein superfamily, SETDB2 is known to be a histone methyltransferase involved in left-right axis specification in early development and mitosis. Synonyms for this target antigen include SET domain bifurcated 2, chronic lymphocytic leukemia deletion region gene 8 protein, lysine N-methyltransferase 1F, and histone-lysine N-methyltransferase SETDB2. SETDB2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of SETDB2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunofluorescence are also common applications.