Anti-TOP2 antibodies enable researchers to detect and measure the TOP2 antigen in biological samples. This target is a reported synonym of the TOP2A gene, which encodes DNA topoisomerase II alpha. This protein is known to function in DNA damage pathways and hematopoietic progenitor cell differentiation, among other biological roles. The human version of TOP2 has a canonical amino acid length of 1531 residues and a protein mass of 174.4 kilodaltons, although 4 isoforms have been identified. It is reported to be localized in the nucleus and cytoplasm of cells and notably expressed in many tissues, such as the bone marrow and lymph node. This target antigen may also be known as TOP2alpha. Some TOP2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.