Anti-SLC14A2 antibodies are used in the immunodetection of the protein solute carrier family 14 member 2. In humans, the canonical protein has a reported length of 920 amino acid residues and a mass of 101.2 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. A member of the Urea transporter protein family, SLC14A2 is known to mediate the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Post-translational modifications have been described, including glycosylation.
The SLC14A2 marker can be used to identify Inner Medullary Collecting Duct Cells, Type 1 Descending Thin Limb Cells, and Type 3 Descending Thin Limb Cells.* Synonyms for this target antigen include UT-A2, UT2, UTA, UTR, hUT-A6, urea transporter 2, solute carrier family 14 (urea transporter), member 2, and HUT2. SLC14A2 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4