Anti-sestrin 2 antibodies are used in the immunodetection of the protein encoded by the SESN2 gene. In humans, the canonical protein has a reported length of 480 amino acid residues and a mass of 54.5 kDa. Its subcellular localization is in the cytoplasm. It is widely expressed across many tissue types. A member of the Sestrin protein family, it is known to function as a intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. Post-translational modifications have been described, including ubiquitination and phosphorylation. Other names for this target antigen include hypoxia induced gene 95 and hypoxia-induced.