Anti-AKR1C1 antibodies are used in the immunodetection of the protein aldo-keto reductase family 1 member C1. In humans, the canonical protein has a reported length of 323 amino acid residues and a mass of 36.8 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. A member of the Aldo/keto reductase protein family, AKR1C1 is known to be involved with cholesterol metabolism and homeostasis and epithelial cell differentiation. The AKR1C1 marker can be used to identify Prostatic Urethra Hillock Cells, Ureter Urothelium Intermediate Cells, and Bladder Urothelium Intermediate Cells.* Synonyms for this target antigen include 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, and 2-ALPHA-HSD.
*HuBMAP Human Reference Atlas v1.4