Anti-PTPRT antibodies are used in the immunodetection of the protein protein tyrosine phosphatase receptor type T. In humans, the canonical protein has a reported length of 1441 amino acid residues and a mass of 162.1 kDa. Its subcellular localization is in the membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in colon, lung, heart and testis, as well as in fetal and adult brain. A member of the Protein-tyrosine phosphatase protein family, PTPRT is suspected to be involved in both signal transduction and cellular adhesion in the CNS.
The PTPRT marker can be used to identify Deep-Layer Near-Projecting Neurons.* Synonyms for this target antigen include RPTP-rho, RPTPrho, receptor-type tyrosine-protein phosphatase T, receptor protein tyrosine phosphatase, receptor-type tyrosine-protein phosphatase rho, and R-PTP-T. PTPRT gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some PTPRT antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4