Anti-PRUNE1 antibodies are used in the immunodetection of the protein prune exopolyphosphatase 1. In humans, the canonical protein has a reported length of 453 amino acid residues and a mass of 50.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 7 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the PPase class C protein family, PRUNE1 is reported to be a Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. The PRUNE1 gene has been associated with the disease, Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies. Synonyms for this target antigen include Drosophila-related expressed sequence 17, protein prune homolog 1, and exopolyphosphatase PRUNE1. PRUNE1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Immunohistochemistry is the most common application for the PRUNE1 antibodies listed below. ELISA, Western Blot, and Immunofluorescence are also common applications.