Anti-TINAG antibodies are used in the immunodetection of the protein tubulointerstitial nephritis antigen. In humans, the canonical protein has a reported length of 476 amino acid residues and a mass of 54.6 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the kidney cortex, small intestine and cornea. A member of the Peptidase C1 protein family, TINAG is known to mediate adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. Post-translational modifications have been described, including glycosylation. The TINAG marker can be used to identify Lower Rhombic Lip Neurons.* TINAG gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Western Blot is a widely used application for the TINAG antibodies listed below. In addition, Immunofluorescence is also a common application.
*HuBMAP Human Reference Atlas v1.4