Anti-C1QA antibodies are used in the immunodetection of the protein complement C1q A chain. In humans, the canonical protein has a reported length of 245 amino acid residues and a mass of 26 kDa. It has been described to be a secreted protein. It is notably expressed in many tissues, such as the lung and skin. C1QA is known to be involved with pathways of aging and cell to cell signaling. Post-translational modifications have been described, including glycosylation.
The C1QA marker can be used to identify Macrophages, Dendritic Cells, Thymic Macrophages, Thymic Cortical Macrophages, and Thymic Medullary Macrophages.* Synonyms for this target antigen include complement C1q subcomponent subunit A, complement C1q chain A, complement component 1, q subcomponent, A chain, complement component 1, q subcomponent, alpha polypeptide, and C1QD1. C1QA gene orthologs have been reported in the mouse, rat, bovine, frog and chicken species. Over 110 citations in the literature describe the use of C1QA antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4