Anti-MCTP1 antibodies are used in the immunodetection of the protein multiple C2 and transmembrane domain containing 1. In humans, the canonical protein has a reported length of 999 amino acid residues and a mass of 111.6 kDa. Its subcellular localization is in the cytoplasmic vesicles and ER. Up to 5 different isoforms have been reported for this protein. A member of the MCTP protein family, MCTP1 is reported to be a calcium sensor, which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.
The MCTP1 marker can be used to identify Descending Vasa Recta Endothelial Cells.* Synonyms for this target antigen include multiple C2 domains, transmembrane 1, multiple C2-domains with two transmembrane regions 1, and multiple C2 and transmembrane domain-containing protein 1. MCTP1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some MCTP1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4