Anti-APC down-regulated 1 antibodies are used for the immunodetection of the protein encoded by the APCDD1 gene. In humans, the canonical protein has a reported length of 514 amino acid residues and a mass of 58.8 kDa. Its subcellular localization is in the cell membrane. It is found to be highly expressed in the heart, pancreas, prostate and ovary. A member of the APCDD1 protein family, it is a reported regulator of the Wnt signaling pathway. Post-translational modifications have been described, including N-glycosylation. The gene encoding this protein is implicated in Hypotrichosis. Other names for this target antigen include adenomatosis polyposis coli down-regulated 1 protein, hypoptrichosis simplex, and protein APCDD1. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of APC down-regulated 1 antibodies have been mentioned in research publications and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.