Anti-ALKAL2 antibodies are used in the immunodetection of the protein ALK and LTK ligand 2. In humans, the canonical protein has a reported length of 152 amino acid residues and a mass of 16.9 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 2 different isoforms have been reported for this protein. It is reported to be widely expressed with highest levels in adrenal gland and modest levels in the pancreas, testis and uterus. A member of the ALKAL protein family, ALKAL2 is a reported cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. The ALKAL2 marker can be used to identify Deep-Layer Intratelencephalic Neurons.* Synonyms for this target antigen include augmentor alpha, augmentor-beta, family with sequence similarity 150 member B, protein FAM150B, and AUG-alpha. ALKAL2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4