Anti-LYPD6 antibodies are used in the immunodetection of the protein LY6/PLAUR domain containing 6. In humans, the canonical protein has a reported length of 171 amino acid residues and a mass of 19.1 kDa. Its subcellular localization is in the cell membrane, cytoplasm, and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the temporal cortex. LYPD6 is known to act as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Post-translational modifications have been described, including glycosylation.
The LYPD6 marker can be used to identify Gray Matter CGE Interneurons and Cerebellar Inhibitory Neurons.* Synonyms for this target antigen include ly6/PLAUR domain-containing protein 6. LYPD6 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some Lypd6 antibodies may have been used in research and have associated citations. Western Blot, Immunocytochemistry, and Immunofluorescence are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4