Anti-HDGF antibodies are used in the immunodetection of the protein heparin binding growth factor. In humans, the canonical protein has a reported length of 240 amino acid residues and a mass of 26.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the HDGF protein family, HDGF is known to act as a transcriptional repressor. Post-translational modifications have been described, including sumoylation and phosphorylation. Synonyms for this target antigen include hepatoma-derived growth factor, epididymis secretory sperm binding protein, hepatoma derived growth factor, high mobility group protein 1-like 2, and HMG1L2. HDGF gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.