Anti-EMX2 antibodies are used in the immunodetection of the protein empty spiracles homeobox 2. In humans, the canonical protein has a reported length of 252 amino acid residues and a mass of 28.3 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the endometrium, smooth muscle, and cerebellum. A member of the EMX homeobox protein family, EMX2 is reported to be a transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. The EMX2 marker can be used to identify Midbrain Splatter Neurons.* Synonyms for this target antigen include empty spiracles homolog 2, empty spiracles-like protein 2, and homeobox protein EMX2. EMX2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4