Anti-SEMG2 antibodies are used in the immunodetection of the protein semenogelin 2. In humans, the canonical protein has a reported length of 582 amino acid residues and a mass of 65.4 kDa. It has been described to be a secreted protein. It is notably expressed in the seminal vesicle. A member of the Semenogelin protein family, SEMG2 is known to participate in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include SGII and semenogelin II.