Anti-OTX2 antibodies are used in the immunodetection of the protein orthodenticle homeobox 2. In humans, the canonical protein has a reported length of 289 amino acid residues and a mass of 31.6 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. A member of the Paired homeobox protein family, OTX2 is reported to be a transcription factor probably involved in the development of the brain and the sense organs.
The OTX2 marker can be used to identify Midbrain Splatter Neurons and Retinal Bipolar Neuron.* Synonyms for this target antigen include MCOPS5, homeobox protein OTX2, orthodenticle homolog 2, and CPHD6. OTX2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 220 citations in the literature describe the use of OTX2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4