Anti-PDE11A antibodies are used in the immunodetection of the protein phosphodiesterase 11A. In humans, the canonical protein has a reported length of 933 amino acid residues and a mass of 104.8 kDa. Its subcellular localization is in the cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Cyclic nucleotide phosphodiesterase protein family, PDE11a is reported to play a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP.
The PDE11A marker can be used to identify Dorsal Excitatory Neurons.* Synonyms for this target antigen include dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP cyclic nucleotide phosphodiesterase 11A, and PPNAD2. PDE11A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some PDE11a antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4