Anti-SPG11 antibodies are used in the immunodetection of the protein SPG11 vesicle trafficking associated, spatacsin. In humans, the canonical protein has a reported length of 2443 amino acid residues and a mass of 278.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in all structures of brain, with a high expression in cerebellum. SPG11 is believed to play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. The SPG11 gene has been associated with the disease, Spastic paraplegia. Synonyms for this target antigen include SPG11, spatacsin vesicle trafficking associated, amyotrophic lateral sclerosis 5, colorectal carcinoma-associated protein, spastic paraplegia 11 (autosomal recessive), and spatacsin. A number of SPG11 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.