Anti-UPK1B antibodies are used in the immunodetection of the protein uroplakin 1B. In humans, the canonical protein has a reported length of 260 amino acid residues and a mass of 29.6 kDa. Its subcellular localization is in the membrane. It is notably expressed in the urinary bladder, stomach, and gallbladder. A member of the Tetraspanin (TM4SF) protein family, Upk1b is a known component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Post-translational modifications have been described, including N-glycosylation.
The UPK1B marker can be used to identify Ureter Urothelium Superficial Cells and Bladder Urothelium Superficial Cells.* Synonyms for this target antigen include UPIB, UPK1, UP1b, tetraspan, tetraspanin-20, tspan-20, uroplakin Ib, and TSPAN20. UPK1B gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some Upk1b antibodies may have been used in research and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4