Anti-MPZ antibodies are used in the immunodetection of the protein myelin protein zero. In humans, the canonical protein has a reported length of 248 amino acid residues and a mass of 27.6 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Myelin P0 protein family, it is known to be involved with chemical synaptic transmission and the regulation of apoptosis. Post-translational modifications have been described, including N-glycosylation. Synonyms for this target antigen include CHN2, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, and CHM.