Anti-AGO1 antibodies are used in the immunodetection of the protein argonaute RISC component 1. In humans, the canonical protein has a reported length of 857 amino acid residues and a mass of 97.2 kDa. Its subcellular localization is in the cytoplasm. A member of the Argonaute protein family, AGO1 is known to be required for RNA-mediated gene silencing (RNAi). Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include EIF2C1, GERP95, NEDLBAS, Q99, hAgo1, protein argonaute-1, Golgi Endoplasmic Reticulum protein 95 kDa, and EIF2C. AGO1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 120 citations in the literature describe the use of AGO1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.