Anti-CCR2 antibodies are used in the immunodetection of the protein C-C motif chemokine receptor 2. In humans, the canonical protein has a reported length of 374 amino acid residues and a mass of 41.9 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is noted to be expressed by monocytes and IL2-activated NK cells. A member of the G-protein coupled receptor 1 protein family, CCR2 is known to be involved with chemotaxis and cytokine-mediated signaling pathways. Post-translational modifications have been described, including N-glycosylation and sulfation.
The CCR2 marker can be used to identify Promonocytes and Classical Inflammatory Monocytes.* Synonyms for this target antigen include MCP-1 receptor, chemokine (C-C motif) receptor 2, monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor, and C-C chemokine receptor type 2. CCR2 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4